Research Group BAKKERS

Hubrecht Institute for Developmental Biology and Stem Cell Research
Contact: Dr. Jeroen Bakkers
E-mail: j.bakkers@hubrecht.eu
Website: http://www.hubrecht.eu/research/bakkers/index.html

General research focus: Cardiac development and genetics

Wide ranges of congenital and acquired human diseases are associated with pathological conditions in heart formation. To understand the complex genetics of congenital heart defects we study cardiac development in the zebrafish model. We use forward and reverse genetics to identify novel genes that are required for normal heart development and use molecular and cellular techniques to characterize gene function in vivo. Subsequently, we use this information to screen for genetic variations in patients with congenital heart defects to better understand the genetics of the disease.

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