Research Group CLEVERS

Hubrecht Institute for Developmental Biology and Stem Cell Research
Contact: Prof. Hans Clevers
E-mail: h.clevers@hubrecht.eu
Website: http://www.hubrecht.eu/research/clevers/index.html

General research focus: Wnt signaling and cancer

Originally focused on T lymphocyte transcription factors, we cloned Tcf1 in 1991. With the discovery that Tcf factors are the final effectors of Wnt signaling, we changed our interests to the biology of Wnt signaling in intestinal self-renewal and cancer.  We identified a series of adult tissue stem cells with the novel Lgr5 marker, currently our major focus of research. 

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