Research Group CUPPEN

Hubrecht Institute for Developmental Biology and Stem Cell Research
Contact: Prof. Edwin Cuppen
E-mail: e.cuppen@hubrecht.eu
Website: http://www.hubrecht.eu/research/cuppen/index.html

General research focus: Genome biology

Technological innovations soon make it possible to read the complete genetic code of an individual for an affordable prize (1,000 dollar genome). However, understanding such personal genomes and the biological consequences of the enclosed genetic variation remains a large challenge. The Cuppen group studies the general mechanisms underlying genotype-phenotype relationships using systematic genomics approaches in rat genetic model systems. A diversity of high-throughput techniques and bioinformatic tools, including next-generation sequencing approaches, are employed to systematically discover and study genetic variation (SNPs, structural variation) and functional genomic elements.

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