Research Group DEN HERTOG

Hubrecht Institute for Developmental Biology and Stem Cell Research
Contact: Prof. Jeroen den Hertog
E-mail: j.denhertog@hubrecht.eu
Website: http://www.hubrecht.eu/research/denhertog/index.html

General research focus: Protein-tyrosine phosphatases in development

Protein phosphorylation on tyrosine residues is an important cell signaling mechanism that is regulated by the antagonistic activities of the protein-tyrosine kinases (PTKs) and protein-tyrosine phosphatases (PTPs). We are interested in the function of PTPs in development and cell signaling. Using biochemical and cell biological approaches, we found that the proto-typical RPTPalpha is regulated by dimerization, oxidation and phosphorylation. The zebrafish is used to elucidate the role of PTPs and PTKs in early vertebrate development. Recently, we found that several PTKs and PTPs are essential for normal convergence and extension cell movements in gastrulation.

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