Research Group KETTING

Hubrecht Institute for Developmental Biology and Stem Cell Research
Contact: Prof. dr. Rene Ketting
E-mail: r.ketting@hubrecht.eu
Website: http://www.hubrecht.eu/research/ketting/index.html

General research focus: RNA silencing

RNA is increasingly being recognized as a very potent effector of gene expression. In particular, RNA interference (RNAi) is a very efficient process in which RNA molecules direct gene silencing by guiding a family of proteins called the Argonaute proteins to their targets. The RNA molecules guiding the silencing effect are quite short, in the range of 21-31 bases, and well studied examples are better known as miRNAs, siRNAs and piRNAs.
Research in the Ketting lab focuses on various aspects of small RNA mediated gene silencing, with a special emphasis on how siRNAs and piRNAs affect the organization and stability of the genome in both vertebrates (zebrafish) and invertebrates (C. elegans).

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