Research Group DE LAAT

Hubrecht Institute for Developmental Biology and Stem Cell Research
Contact: Prof.dr. Wouter de Laat
E-mail: w.delaat@hubrecht.eu
Website: http://www.hubrecht.eu/research/delaat/index.html

General research focus: Biomedical genomics

The architecture of DNA in the interior of the living cell nucleus is an emerging key contributor to genomic function. Aim of our research is to understand how genome structure influences genome function. We use and develop novel genomics approaches such as 4C technology to identify long-range DNA interactions, study gene regulation within and between mammalian chromosomes and uncover the proteins that dictate the shape of our genome. Besides transcription we study the impact of nuclear architecture on genomic rearrangements. Furthermore, we develop novel strategies to identify and map chromosomal aberrations.

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