Research Group GUARDAVACCARO

Hubrecht Institute for Developmental Biology and Stem Cell Research
Contact: Dr. Daniele Guardavaccaro
E-mail: d.guardavaccaro@hubrecht.eu
Website: http://www.hubrecht.eu/research/guardavaccaro/index.html

General research focus: Ubiquitin ligases and cancer

The ubiquitin-proteasome system controls molecular networks that underlie fundamental cellular functions such as DNA replication, DNA repair, transcription, protein synthesis, cell differentiation and apoptosis. A large body of experimental and clinical data reveals that aberrations in the ubiquitin-dependent protein degradation are intimately linked with cancer pathogenesis. The main objective of our research is the elucidation of the molecular mechanisms by which deregulated function of Cullin-RING ubiquitin ligases contribute to oncogenesis. To this end we use an interdisciplinary approach that includes biochemical and cellular biological methods as well as mouse genetics.

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